Expression and function of a T - type Ca 2 + conductance in interstitial 3 cells of Cajal of the murine small intestine
نویسندگان
چکیده
Haifeng Zheng,* Kyung Sik Park+,Sang Don Koh,* Kenton M. Sanders.* 6 7 8 *Department of Physiology and Cell Biology, University of Nevada, School of Medicine, 9 Reno, NV 89557 10 †Department of Internal Medicine, Keimyung University School of Medicine, Daegu, 11 Korea 12 13 14 Running title: T-type Ca conductance in ICC Word count: 4197 * Corresponding author: Kenton M. Sanders, email; [email protected]
منابع مشابه
Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.
Interstitial cells of Cajal (ICC) generate slow waves in gastrointestinal (GI) muscles. Previous studies have suggested that slow wave generation and propagation depends on a voltage-dependent Ca(2+) entry mechanism with the signature of a T-type Ca(2+) conductance. We studied voltage-dependent inward currents in isolated ICC. ICC displayed two phases of inward current upon depolarization: a lo...
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Objective(s): To study the c-Kit expression in the gallbladder of cholesterol lithogenic guinea pig model and the effect of Artemisia capillaris Thunb on interstitial cells of Cajal (ICCs). Materials and Methods:A total of 45 guinea pigs were randomly assigned into three groups: the control group (guinea pigs fed a standard diet, normal group); the model group (guinea pigs fed a cholesterol gal...
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OBJECTIVE To investigate the expression and function of T-type calcium channels in the interstitial cells of Cajal in rat bladders. METHODS Bladders were harvested from Sprague-Dawley rats. The expression of T-type calcium channels subtypes (α1G, α1H, and α1I) in interstitial cells of Cajal were identified by double-labeled immunofluorescence analysis and reverse transcription-polymerase chai...
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Located within the tunica muscularis of the gastrointestinal (GI) tract are networks of cells known as interstitial cells of Cajal (ICC). ICC are critical for important basic functions of GI motility such as generation and propagation of slow-wave pacemaker activity and reception of regulatory inputs from the enteric nervous system. We have developed a novel procedure to identify and isolate in...
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تاریخ انتشار 2014